Property Description
Chemical Name:2,3-Dihydrobenzofuran
Synonyms:Coumaran; Benzofuran, 2,3-dihydro-
CAS Number:496-16-2
Molecular Formula:C<sub>8</sub>H<sub>8</sub>O
Molecular Weight:120.15 g/mol
Appearance:Colorless to pale yellow liquid
Odor:Mild, aromatic
Density：~1.09 g/cm³ (at 20°C)
Melting Point：-30°C to -25°C
Boiling Point：188–190°C
Flash Point：~70°C (closed cup)
Solubility - Water: Slightly soluble
- Organic solvents: Miscible with ethanol, ether, acetone
Refractive Index：~1.55 (at 20°C)
Viscosity Low (liquid at room temperature)
Stability：Stable under normal conditions; sensitive to strong oxidizers
Chemical Class：Heterocyclic compound (benzofuran derivative)
Key Applications：- Pharmaceutical intermediate (e.g., synthesis of darifenacin, anticoagulants)
- Fragrance industry (flavoring agent)
- Organic synthesis (building block for agrochemicals)
Brief Introduction:
2,3-Dihydrobenzofuran is a heterocyclic organic compound consisting of a benzene ring fused with a partially saturated furan ring. It serves as a versatile intermediate in pharmaceuticals (e.g., darifenacin hydrobromide synthesis) and fragrances. Its stability and reactivity make it valuable for constructing complex molecules in medicinal chemistry.
| Test Parameter | Specification | Method (Reference Standard) |
|---|
| Appearance | Colorless to pale yellow clear liquid | Visual (EP/ACS) |
| Identification | - IR spectrum matches reference
- GC retention time conforms | FTIR, GC-FID |
| Purity (GC) | ≥ 99.0% (area percentage) | Gas Chromatography |
| Water Content | ≤ 0.5% (w/w) | Karl Fischer titration |
| Related Substances | - Single impurity: ≤ 0.5%
- Total impurities: ≤ 1.0% | GC (capillary column) |
| Refractive Index | 1.548 - 1.552 (at 20°C) | Abbe refractometer |
| Density | 1.085 - 1.095 g/cm³ (at 20°C) | Digital densitometer |
| Boiling Point | 188 - 190°C | Distillation (ASTM D86) |
| Residual Solvents | - Methanol ≤ 500 ppm
- Toluene ≤ 890 ppm (if used in synthesis) | GC-HS |
| Heavy Metals | ≤ 10 ppm (as Pb) | ICP-OES |
| Sulfated Ash | ≤ 0.1% | Gravimetric (USP <281>) |
| Microbial Limits | - TAMC ≤ 10³ CFU/g
- TYMC ≤ 10² CFU/g (if for pharma use) | USP <61>, <62> |
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