| Name | 27-Hydroxycholesterol |
| Description | 27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor. |
| In vitro | 27-Hydroxycholesterol activates estrogen receptors, adversely impacting prostate cancer cell lines by significantly enhancing cell proliferation in LNCaP and PC3 cells. This proliferation can be mitigated by estrogen receptor inhibitors [1]. As an endogenous selective estrogen receptor modulator, 27-Hydroxycholesterol exhibits substantial partial agonist activity across various cellular models, notably increasing gene transcription and cell proliferation in breast cancer contexts [2]. Produced from cholesterol by the enzyme CYP27A1, it plays a vital role in regulating intracellular cholesterol equilibrium. Its pro-tumorigenic effects can be diminished by either statins or directly inhibiting CYP27A1 [3]. Furthermore, 27-Hydroxycholesterol's conversion from cholesterol is crucial for LXR activation when faced with cholesterol excess [4]. |
| Storage | keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMF : 2 mg/mL (4.97 mM), Sonication is recommended.
DMSO : 0.1 mg/mL (0.25 mM), Sonication is recommended.
10% EtOH+90% Corn Oil : 1 mg/mL (2.48 mM), Sonication is recommended.
Ethanol : ≤ 20 mg/mL (49.66 mM), Sonication is recommended.
|
| Keywords | progestogenReceptor | progestogen Receptor | LXR agonist | LXR | LiverXReceptor | Liver X Receptor | EstrogenReceptor | Estrogen Receptor | ER modulator | ER | 27-Hydroxycholesterol | 27Hydroxycholesterol | 27 Hydroxycholesterol | 2527-hydroxy Cholesterol | 25(R)-27-hydroxy Cholesterol |
| Inhibitors Related | Sucrose | Aceglutamide | L-Pyroglutamic acid | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Formamide | Glycerol | Thymidine | Corn starch | Hyaluronic acid sodium (MW 20 kDa) | Gluconate Calcium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Nuclear Receptor Compound Library | Bioactive Compound Library | Natural Product Library | Endocrinology-Hormone Compound Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Mouse Metabolite Compound Library | Human Metabolite Library | Transcription Factor-Targeted Compound Library |
United States
