| Name | 3-Carene |
| Description | 3-Carene(Delta-3-Carene) is a bicyclic monoterpene extracted from western larch and Douglas-fir that acts as a phytofungicide.3-Carene inhibits inflammatory infiltrates and COX-2 overexpression induced by nociceptive stimuli.3-Carene has anti-injury properties and promotes the activity and expression of alkaline phosphatase, an early marker of osteoblast differentiation. |
| In vitro | Rat alveolar macrophages were incubated with the monoterpene 3-Carene (0, 0.005, 0.05, 0.5, and 5.0 μM; 75 min; Rat alveolar macrophages) in culture medium for 75 min. A dose-dependent relationship was found between the cell viability and the 3-Carene concentration. At 5.0 μM 3-Carene, 98% of the AM were dead. The phagocytosis of heat-killed yeast particles was significantly decreased and the attachment of particles to the cell surface significantly increased at 0.5 μM 3-Carene. Electron microscopy showed that about 50% of the AM lacked or had very few surface protrusions after incubation in 0.5 μM 3-Carene. Thus, 3-Carene seemed to affect mainly the engulfment of particles. Surfactant, 0.5 mg/ml as Curosurf, added to the incubation medium, did not affect the AM reaction to 3-Carene exposure.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (367.03 mM), Sonication is recommended.
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| Keywords | Δ-3-Carene | Fungal | COX-2 | 3-Carene |
| Inhibitors Related | Dehydroacetic acid sodium | Chlorobutanol hemihydrate | 2-Butyl-1,2-benzisothiazolin-3-one | Potassium gluconate | Chitosan (MW 150000) | Bismuth Subsalicylate | Methyl 2-amino-5-bromobenzoate | Acetaminophen | Lauryl betaine | Geraniol | Paradol | Salicylic acid |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Selected Plant-Sourced Compound Library | Anti-Fungal Compound Library | Natural Product Library | Miao medicine Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Anti-infective Natural Product Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Food as Medicine Compound Library |
United States
