| Name | 3'-Sialyllactose sodium |
| Description | 3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis. |
| In vitro | For 24-36 hours at concentrations ranging from 0 to 250 μM, 3'-Sialyllactose sodium promotes and restores Col2a1 synthesis, accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].In chondrocytes, 3'-Sialyllactose sodium (0-250 μM; 24 hours) activates the expression of Sox9 and inhibits NF-κB activation[3].In the presence or absence of metabolic activation, 3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect and does not exhibit evident growth inhibition and deposition in all strains[1].At a concentration of 1250 μg/mL, 3'-Sialyllactose sodium induces no chromosomal aberrations and demonstrates a non-clastogenic effect in either the presence or absence of metabolic activation[1]. |
| In vivo | For 6 weeks, mice were orally administered 3'-Sialyllactose sodium at doses of 10-100 mg/kg three times a week, protecting them against cartilage destruction from osteoarthritis[3].A single oral administration of 3'-Sialyllactose sodium at doses of 500, 1000, and 2000 mg/kg induces no micronuclei in the bone marrow cells of mice[1].In male and female beagle dogs, the maximum tolerance dose (MTD) of 3'-Sialyllactose sodium, given orally at doses ranging from 500 to 1000 to 2000 mg/kg at 4-day intervals, is greater than 2000 mg/kg[3].3'-Sialyllactose sodium demonstrates a lethal dose (LD50) above 20 g/kg bw, which is the highest tested dose[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5 mg/mL (7.63 mM), Sonication is recommended.
H2O : 100 mg/mL (152.55 mM), Sonication is recommended.
PBS (pH 7.2) : 10 mg/mL (15.25 mM), Sonication is recommended.
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| Keywords | NF-κB | NFκB | NF-kB | NFkB | 3'Sialyllactose (sodium salt) | 3'-Sialyllactose | 3' Sialyllactose (sodium salt) |
| Inhibitors Related | Undecane | Sodium propionate | Ethyl palmitate | Kojic acid | Uridine | Fumaric acid | Methylamine HCl | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | N,N-Dimethylacetamide | Magnesium sulfate |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Ovarian Cancer Compound Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Covalent Natural Product Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Transcription Factor-Targeted Compound Library |
United States
