| Name | 3β-Ursodeoxycholic acid |
| Description | 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid that exhibits good tolerance and good intestinal absorption when administered orally.3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) can undergo enzymatic isomerization in the intestines and the 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) undergoes enzymatic isomerization in the intestine and liver and produces UDCA. |
| In vitro | METHODS: Hep G2 cells were treated with 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) (100 μM) and ethanol (80 μM) to investigate the effects of 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) and ethanol on Hep G2 cells. The cytotoxic effects of 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) and ethanol on Hep G2 cells were investigated, as well as the interactions between them.
RESULTS 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) did not show any cytotoxic effects and could be cytoprotective against ethanol-induced cell damage. [4]
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| In vivo | METHODS: 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) or UDCA (2.5 g/kg, orally, for 3 weeks) were given to rats , respectively , to compare the metabolism of UDCA and 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) in experimental cholestasis and the effects on cholestasis in rats.
RESULTS3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) was completely converted to UDCA in the liver; cholestasis and cholestatic bile acids were identical after intraduodenal administration of either compound. Oral administration of UDCA or 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) significantly improved hepatic biochemistry in chronic cholestasis, but not clinical and histologic parameters. [1]
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| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (8.41 mM), Sonication is recommended.
DMSO : 135 mg/mL (343.89 mM), Sonication is recommended.
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| Keywords | 3β-Ursodeoxycholic acid | 3b-Ursodeoxycholic acid | 3beta-Ursodeoxycholic acid |
| Inhibitors Related | H-ASP-PHE-OH | 2-(Methylamino)benzoic acid | Melamine | Mycophenolate Mofetil | Clozapine N-Oxide | 10-Undecen-1-ol | 2-Carboxybenzaldehyde | Isonicotinic acid | Urolithin A | 4-Carboxypyrazole | Lansoprazole sulfide | 4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide |
| Related Compound Libraries | Food Sourced Compound Library | Bioactive Compound Library | Natural Product Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Orally Active Compound Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Gut Microbial Metabolite Library | Human Metabolite Library | Bile Acids Library |
United States
