| Name | 3,3'-Diindolylmethane |
| Description | 3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent. |
| Cell Research | The 184A1 and Hs578Bst cells are pretreated with DIM (0.3 μM) or vehicle for 24 h, irradiated by using different doses of 137Cs γ rays, harvested, plated at different densities, incubated for 14 d, and counted for colony formation.(Only for Reference) |
| In vitro | 3,3'-Diindolylmethane is a potent radioprotector and mitigator that functions by stimulating an ATM-driven DDR-like response and NF-κB survival signaling. 3,3'-Diindolylmethane can inhibit invasion, angiogenesis, and proliferation and induce apoptosis in tumor cells by modulating signaling pathways involving AKT, NF-κB, and FOXO3. It can also inhibit estrogen-inducible gene expression and cause an endoplasmic reticulum stress response. 3,3'-Diindolylmethane alters estrogen metabolism by shifting metabolism from carcinogenic 16α-hydroxy to inert 2-hydroxy derivatives, and it antagonizes estrogen and androgen receptor activity[1]. |
| In vivo | Preliminary studies show 3,3'-Diindolylmethane is most effective against total body irradiation (TBI) when given in multiple once-daily doses. Treatment of 3,3'-Diindolylmethane has radioprotection and mitigation properties in vivo. 3,3'-Diindolylmethane Activates ATM in Normal Tissues. 3,3'-Diindolylmethane can be given to mice (250 mg/kg) by oral gavage, with no acute toxicity and excellent bioavailability[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 18 mg/mL (73.08 mM), Sonication is recommended.
DMSO : 500 mg/mL (2029.96 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.12 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | HB-236 | HB236 | Autophagy | AndrogenReceptor | Androgen Receptor | 3,3'-Diindolylmethane | 3,3'Diindolylmethane | 3,3' Diindolylmethane |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Autophagy Compound Library | Anti-Cancer Clinical Compound Library | Natural Product Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
