| Name | 3',4'-Dihydroxyflavonol |
| Description | 3',4'-Dihydroxyflavonol (DiOHF) is an effective antioxidant that reduces ROS and superoxide production in the mesenteric arteries of diabetic rats, increases total eNOS expression, and improves nitric oxide (NO) activity. |
| In vitro | 3',4'-Dihydroxyflavonol (DiOHF) exhibits significant vascular protective effects under oxidative stress conditions, maintaining the biological activity of nitric oxide (NO) through multiple mechanisms. This compound can effectively alleviate the vasoconstrictive response of the tertiary branches of the rat mesenteric artery through Ca²⁺ desensitization, thereby reducing vascular permeability. At the same time, DiOHF significantly improves NO activity and endothelial function in pathological conditions such as diabetes by inhibiting Nox2-dependent superoxide production and preventing eNOS uncoupling. These synergistic effects make DiOHF a potential vascular function regulator, especially in pathological conditions with elevated reactive oxygen species levels, showing important therapeutic value. [1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (370.04 mM), Sonication is recommended.
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| Keywords | 3',4'-Dihydroxyflavonol | 3',4'Dihydroxyflavonol | 3',4' Dihydroxyflavonol |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | Copper Sulfate Pentahydrate | Methylene Blue trihydrate | L-Ascorbic acid sodium salt | Gluconate Calcium | Dimethyl phthalate |
| Related Compound Libraries | Bioactive Compound Library | Antioxidant Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
