| Name | 3,4-O-Isopropylidene-shikimic acid |
| Description | 3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) exhibits significant anti-inflammatory, anti-thrombosis, antioxidant, and analgesic effects, and provides protective benefits against trinitrobenzenesulfonic acid-induced experimental colitis in rats, likely because of its antioxidant properties. |
| In vitro | 3,4-O-Isopropylidene shikimic acid (ISA,1-100 micromol/L) effectively reduced PMN adhesion to TNF-alpha-induced HUVEC with the inhibitory rate from 17.2 % to 53.5 % and exerted no effect on PMN adhesion to normal HUVEC. Adhesion molecule ICAM-1 surface protein and mRNA expression induced by TNF-alpha (400 kU/L) were significantly inhibited by ISA. In addition, the cell viability of HUVEC was unchanged 48 h after treatment with ISA[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (280.09 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.34 mM), Sonication is recommended.
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| Keywords | shikimic | PGE | NOSynthase | NOS | NO Synthase | Inhibitor | inhibit | antioxidant | anti-inflammatory | acid | 3,4-O-Isopropylidene-shikimic acid | 3,4OIsopropylideneshikimic acid | 3,4 O Isopropylidene shikimic acid |
| Inhibitors Related | 2-Isopropyl-1H-imidazole | Chondroitin sulfate | L-NAME hydrochloride | Mifepristone | Aminopicoline | Agmatine sulfate | 3-AMINO-1,2,4-TRIAZINE | Nitroarginine | Methylene Blue trihydrate | Gluconate Calcium | Diallyl disulfide | Magnesium sulfate |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Antioxidant Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Neuroprotective Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |