| Name | 3,5,6,7,8,3',4'-Heptemthoxyflavone |
| Description | 3,5,6,7,8,3',4'-Heptemthoxyflavone exhibits neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging, and photoprotective effects; it inhibits collagenase activity, induces type I procollagen synthesis in HDFn cells, and combats nitric oxide (NO) carcinogenesis. |
| In vitro | 3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF), extracted from C. unshiu peels using ethanol extraction and hexane fractionation, inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells. HMF also suppressed matrix metalloproteinases 1 (MMP-1) expression and induced type I procollagen protein expression in these cells. Additionally, HMF inhibited UVB-induced phosphorylation of MAPK cascade signaling components—ERK, JNK, and c-Jun—thereby reducing MMP-1 expression. Furthermore, HMF modulated the TGF-β/Smad signaling pathway by inducing Smad3 and suppressing Smad7 protein expressions in a dose-dependent manner in UV-induced HDFn cells. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (115.63 mM), Sonication is recommended. 10% DMSO+90% Corn Oil : 1 mg/mL (2.31 mM), Sonication is recommended.
|
| Keywords | TNF-α | Inhibitor | inhibit | IL Receptor | gp120/CD4 | 3,5,6,7,8,3',4'-Heptemthoxyflavone | 3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone | 3,5,6,7,8,3',4'Heptemthoxyflavone | 3,5,6,7,8,3',4' Heptemthoxyflavone |
| Inhibitors Related | Balipodect | Theophylline monohydrate | D(+)-Raffinose pentahydrate | Theobromine | Apremilast | Isoprenaline hydrochloride | Indomethacin | Icariin | Theophylline | Vardenafil hydrochloride | Sildenafil citrate | Doxofylline |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Miao medicine Compound Library | Neuroprotective Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library |