| Name | 4-Vinylphenol |
| Description | 4-Vinylphenol is the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine found in Hedyotis diffusa Willd. 4-Vinylphenol induces apoptosis in vivo. |
| In vitro | 4-Vinylphenol (100 µg/mL) notably enhances caspase 3 expression, effectively making CSC-enriched MDAMB-231 cells more prone to apoptosis. At concentrations of 50 and 100 µg/mL, it dramatically inhibits cell proliferation in these cells. Furthermore, 4-Vinylphenol at a range of 12.5-200 µg/mL substantially decreases cell viability in parental MDA-MB-231 cells, with an IC50 value determined at 109 µg/mL. At lower doses (0.15, 0.3 µg/mL), it diminishes sphere formation and vimentin expression in CSCs, indicative of its potential in targeting breast cancer. Notably, 4-Vinylphenol cuts down ALDH1A1 expression by half in CSC-enriched MDA-MB-231 cells[1]. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (27.47 mM), Sonication is recommended.
DMSO : 250 mg/mL (2080.73 mM), Sonication is recommended.
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| Keywords | vessels | tumor | invasive | Inhibitor | inhibit | formation | EndogenousMetabolite | Endogenous Metabolite | breast | blood | Apoptosis | 4-Vinylphenol | 4Vinylphenol | 4 Vinylphenol |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Apoptosis Compound Library | Medicinal and aromatic plants natural product library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Tobacco Monomer Library | Natural Product Library for HTS | Flavor Natural Product library | Bioactive Compounds Library Max | Food as Medicine Compound Library |
United States
