4,6-Dichloroisatin NEW

$2.20 100kg

$6.60 10kg

$8.80 1kg

Min. Order1kg
Purity99%min
Cas No18711-15-4
Supply Ability100kg
Update time2025-10-13

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

VIP1Y

China

Chemical Properties

Product Name	4,6-Dichloroisatin
CAS No	18711-15-4
EC-No
Min. Order	1kg
Purity	99%min
Supply Ability	100kg
Release date	2025/10/13

4,6-Dichloroisatin

Modify Date: 2025-08-25 12:16:47

4,6-Dichloroisatin structure	Common Name	4,6-Dichloroisatin
	CAS Number	18711-15-4	Molecular Weight	216.02
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C8H3Cl2NO2	Melting Point	260.5-261°C
	MSDS	N/A	Flash Point	N/A

Purity		Quantity		Budget		Inquiry

Use of 4,6-Dichloroisatin

CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].

Properties
Spectrum

Name	4,6-dichloro-1h-indole-2,3-dione
Synonym	More Synonyms

Description	CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRAS(G12C)
In Vitro
In Vivo	Animal Model: NOD/SCID female mice (KRasWT (LCLC-103H) or KRasG12C (H1792) tumors)[1] Dosage: 5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments Administration: I.p. Result: Reduced tumor growth compared to the control group in KRasG12C mutated model for 35.8%.
References	[1]. Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212.

Density	1.6±0.1 g/cm3
Melting Point	260.5-261°C
Molecular Formula	C8H3Cl2NO2
Molecular Weight	216.02
Exact Mass	214.954086
PSA	46.17000
LogP	2.20
Index of Refraction	1.638

Hazard Codes	T+
RIDADR	2811.0
HS Code	2933990090

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