| Name | (4E)-SUN9221 |
| Description | (4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist, exhibiting antihypertensive and antiplatelet aggregation activities in hypertensive rats. |
| In vitro | In human platelet-rich plasma (PRP), (4E)-SUN9221 potently inhibits collagen-, ADP-, and epinephrine-induced platelet aggregation, with IC50s of 10 nM, 35 nM, and 14 nM, respectively. Additionally, (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22)[1]. |
| In vivo | In conscious spontaneously hypertensive rats (SHR), (4E)-SUN9221 reduces blood pressure in a dose-dependent manner when administered orally at doses of 1, 3, and 10 mg/kg. Specifically, (4E)-SUN9221 at a dose of 3 mg/kg exhibits antihypertensive activity in SHR[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | α1A-adrenergic receptor | SUN-9221 | SUN9221 | SUN 9221 | AdrenergicReceptor | Adrenergic Receptor | 5HTReceptor | 5-HT2 | 5HT Receptor | (4E)-SUN-9221 | (4E)SUN9221 | (4E) SUN9221 |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | Octopamine hydrochloride | 1,8-Cineole | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | D-Mannitol | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Anti-Cardiovascular Disease Compound Library | Endocrinology-Hormone Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library |