| Name | 5-Aminosalicylic Acid |
| Description | 5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1(PAK1) and NF-Κb. 5-Aminosalicylic Acid has anti-cancer and anti-inflammatory activities. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN). |
| In vitro | METHODS: HEK293 cells carrying the pendrin P123S mutant were treated with 5-Aminosalicylic Acid for 72 hours, and cytotoxicity was detected by the MTT method.
RESULTS: The IC50 of 5-Aminosalicylic Acid on HEK293 cells carrying the pendrin P123S mutant was >15 mM. [1] |
| In vivo | METHODS: To study the anti-tumor activity of 5-Aminosalicylic Acid, 5-Aminosalicylic Acid (50 mM) was administered to SCID mice inoculated with HT-29 colon cancer cells for 21 consecutive days.
RESULTS: The tumor weight and volume of SCID mice treated with 5-Aminosalicylic acid were reduced by 80-86%. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (21.55 mM), Sonication is recommended.
Ethanol : 29 mg/mL (189.37 mM), Sonication is recommended.
DMSO : 80 mg/mL (522.4 mM), Sonication is recommended.
|
| Keywords | PPARγ | PPAR | Peroxisome proliferator-activated receptors | PAK | p21 activated kinases | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | MPO | Inhibitor | inhibit | GlutathionePeroxidase | Glutathione Peroxidase | EndogenousMetabolite | Endogenous Metabolite | COX | ALOX5 | 5-Aminosalicylic Acid | 5Aminosalicylic Acid | 5 Aminosalicylic Acid |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Ethyl linoleate | Malic acid | Glycerol | Thymidine | Trometamol | Gluconate Calcium |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Natural Product Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | FDA-Approved Kinase Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
