| Name | 5-hydroxytryptophan |
| Description | 5-Hydroxytryptophan (NSC-92523) is a metabolite of tryptophan and a direct precursor of serotonin. It is a substrate of aromatic amino acid decarboxylase and can be used to induce depression models. |
| In vitro | 5-Hydroxytryptophan exhibits toxicity in mice with an LD50 of 1800 mg/kg. In rats, it demonstrates effects at a dosage of 300 mg/kg when administered intragastrically (i.g.). |
| In vivo | 5-Hydroxytryptophan is an intermediate in the biosynthesis of serotonin from the essential amino acid L-tryptophan, which can easily cross the blood-brain barrier and effectively increase the synthesis of serotonin within the central nervous system. It has been shown to improve conditions such as depression, chronic headaches, and insomnia. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.08 mM), Sonication is recommended.
DMSO : 250 mg/mL (1135.23 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : 4 mg/mL (18.16 mM), Sonication is recommended.
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| Keywords | NSC92523 | NSC 92523 | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | 5-Hydroxytryptophan | 5hydroxytryptophan | 5-HTP | 5 hydroxytryptophan | 114-03-4 |
| Inhibitors Related | Sucrose | Aceglutamide | L-Pyroglutamic acid | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Formamide | Glycerol | Thymidine | Corn starch | Hyaluronic acid sodium (MW 20 kDa) | Gluconate Calcium |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Natural Product Library | CNS-Penetrant Compound Library | NO PAINS Compound Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library |
United States
