| Name | 5-O-Caffeoylshikimic acid |
| Description | 5-O-Caffeoylshikimic acid shows anti-oxidative activity; it also shows anti-inflammatory activity, the underlying mechanism was associated with downregulation of nuclear factor-κB. |
| In vitro | Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line.Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated for antiproliferative effect and modulation of drug accumulation. RESULTS: The growth inhibitory dose (ID50) of the compounds ranged from 12.64 to 20.62 mug/ml. Methylprototribestin was the most effective resistance modifier. However, methylprotodioscin, pseudoprotodioscin, prosapogenin A of dioscin, tribestin and 5-O-Caffeoylshikimic acid showed moderate MDR reversal activity. In a checkerboard method, methyloprototribestin and the mixture of the 3 acetylated isomers enhanced the antiproliferative effects on MDR cells in combination with doxorubicin. CONCLUSION: Based on these results, methylprototribestin and the mixture of the 3 acetylated isomers can be recommended for further in vivo experiments in combination with anthracyclines in human MDR-cancer xenograft transplanted mice[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.95 mM), Sonication is recommended.
DMSO : 50 mg/mL (148.68 mM), Sonication is recommended.
H2O : 20 mg/mL (59.47 mM), Sonication is recommended.
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| Keywords | TNF-α | NOSynthase | NO Synthase | Inhibitor | inhibit | ILReceptor | IL Receptor | 5-O-Caffeoylshikimic acid | 5OCaffeoylshikimic acid | 5 O Caffeoylshikimic acid |
| Inhibitors Related | Kaolin | Acetylcysteine | Ethyl palmitate | Gum arabic | 1,8-Cineole | Aminopicoline | 1,4-Naphthoquinone | Tributyrin | Glucosamine | Methylene Blue trihydrate | Gluconate Calcium | Magnesium sulfate |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Rare Natural Product Library | Membrane Protein-targeted Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
United States
