| Name | 5-O-Demethylnobiletin |
| Description | 5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2. |
| In vitro | 5-DEMETHYLNOBILETIN promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[1]. |
| In vivo | 5-O-Demethylnobiletinreduced the oedema formation, cell infiltration, and tissue damage in the inflammation induced by TPA in mouse ears, along with the acute oedema induced by carrageenan in mouse paws and the acute PLA -induced oedema in mouse paws.The flavone inhibited leukotriene B formation in rat neutrophils and elastase release in human neutrophils, but did not reduce the expression of cyclooxygenase-2 (COX-2) in murine RAW 264.7 macrophages.These experimental results suggest that 5-O-Demethylnobiletinmay actthrough a direct inhibition of 5-LOX, without affecting the expression of COX-2[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.89 mg/mL (10.02 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.57 mM), Sonication is recommended.
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| Keywords | LOX | Lipoxygenase | LeukotrieneReceptor | Leukotriene Receptor | Inhibitor | inhibit | 5-O-Demethylnobiletin | 5ODemethylnobiletin | 5 O Demethylnobiletin |
| Inhibitors Related | Montelukast sodium | 2,5-Di-tert-butylhydroquinone | Caffeic Acid | 5-LOX inhibitor | 3-Aminobutanoic acid | Phenidone | 4-Aminosalicylic acid | Cuminaldehyde | NNK | Olsalazine disodium | Malotilate | 5-Aminosalicylic Acid |
| Related Compound Libraries | Flavonoid Natural Product Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
