| Name | 5Z-7-Oxozeaenol |
| Description | 5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM. |
| In vitro | 5Z-7-Oxozeaenol is a natural anti-protozoan compound from the fungal origin with inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC with IC50s of 110, 170, 340, 6300, and 6600 nM, respectively[1]. 5Z-7-Oxozaeenol inhibited PMA-induced AP-1 activity to almost basal levels in KT cells but had no effect on IL-1-induced NF-kB activity in KK cells[2]. 5Z-7-Oxozaeenol inhibits the JNK/p38 pathway, but it is not a direct inhibitor and is signal-specific. 5Z-7-Oxozaeenol prevents inflammation by inhibiting the catalytic activity of the TAK1 MAPK kinase[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 40 mg/mL (110.38 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2 mg/mL (5.52 mM), Sonication is recommended.
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| Keywords | VEGFR-3 | VEGFR3 | VEGFR-2 | VEGFR2 | VEGFR | Vascular endothelial growth factor receptor | TAK1 | Src | PDGFR-β | PDGFRβ | MEK1 | MAP3K | MAP kinase kinase kinase, MEKK, MAPKKK | L-783279 | L 783279 | Inhibitor | inhibit | FR-148083 | FR 148083 | FLT3 | B-RAF VE | B-Raf (VE) | Antibiotic | 5Z-7-Oxozeaenol | 5Z7Oxozeaenol | 5Z 7 Oxozeaenol |
| Inhibitors Related | Neomycin sulfate | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Avermectin B1a | Doxycycline | Penicillin G sodium salt | Penicillin G potassium | EDTA copper(II) disodium salt | Ethyl acetoacetate |
United States
