| Name | 6-(γ,γ-Dimethylallylamino)purine |
| Description | 6-(γ,γ-Dimethylallylamino)purine (Triacanthine), which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic. |
| In vitro | 6-(γ,γ-Dimethylallylamino)purinee significantly inhibited EJ cell proliferation (IC50 600μM). Flow cytometry analysis revealed that cells were arrested in the G1 phase, and apoptotic cells accumulated in the sub-G1 phase in a dose-dependent manner. 6-(γ,γ-Dimethylallylamino)purinee inhibited the G1-S transition by deterring complex formation between cyclin-dependent kinases and cyclins, thereby up-regulating cell cycle inhibitors p21WAF1 and p27KIP1. |
| In vivo | In an in vivo study, 6-(γ,γ-Dimethylallylamino)purinee significantly limited growth of xenografted tumors. Interestingly, while cisplatin resulted in significant weight loss after a 5-mg/kg dose, 6-(γ,γ-Dimethylallylamino)purinee did not cause weight loss, behavioral abnormalities, altered biochemical parameters, or tissue staining. A single oral dose acute-toxicity test (6-(γ,γ-Dimethylallylamino)purinee 2,000mg/kg) produced no adverse cytotoxic effects via blood biochemical tests and tissue-organ staining. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (4.92 mM), Sonication is recommended.
DMSO : 32.33 mg/mL (159.07 mM), Sonication is recommended.
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| Keywords | Inhibitor | inhibit | 6-(γ,γ-Dimethylallylamino)purine | 6(γ,γDimethylallylamino)purine | 6-(r,r-Dimethylallylamino)purine | 6-(gamma,gamma-Dimethylallylamino)purine | 6 (γ,γ Dimethylallylamino)purine |
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United States
