| Name | 6PPD-Q |
| Description | 6PPD-Q (6PPD-Quinone) is an environmental pollutant that can target CNR2, CNR1, AA2AR, LCAT and TRPA1. Among them, CNR2 has the highest binding affinity and may act as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q can damage the sperm quality and induce the impairment of male reproductive ability in mice. 6PPD-Q can induce intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolytic metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. |
| In vitro | METHODS: Mouse dopaminergic neurons were treated with 6PPD-Q (10 nM, 100 nM) for 48 hours to detect cell growth inhibition.
RESULTS: R6PPD-Q did not exhibit significant cytotoxicity. [1]
METHODS: Mouse dopaminergic neurons were treated with 6PPD-Q (10 nM, 100 nM) for 7 days, and target protein expression was detected by Western Blot.
RESULTS: R6PPD-Q significantly increased Triton X-100-insoluble α-synuclein (α-syn) protein levels. [1] |
| In vivo | METHODS: To study the effect of 6PPD-Q on intestinal injury, 6PPD-Q (0.1, 1, 10, 100 μg/kg) was orally administered to ICR mice once daily for 21 days.
RESULTS: 6PPD-Q caused intestinal injury in ICR mice, which was manifested as enhanced inflammatory response in jejunum and ileum and impaired intestinal barrier integrity. [2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (33.51 mM), Sonication and heating are recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | EndogenousMetabolite | Endogenous Metabolite | 6PPD-Q |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Bioactive Compound Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
United States
