| Name | 7-Methylguanine |
| Description | 7-Methylguanine is an orally available PARP1 inhibitor (Ki=61 μM) that competes with the substrate NAD+, exhibiting anticancer activity. As a natural nucleic acid metabolite, it may serve as a probe for protein-DNA interactions. |
| In vitro | 7-Methylguanine (0-200 μM) inhibits the activity of PARP1 enzyme in a dose-dependent manner [1].
7-Methylguanine is a competitive PARP-1 inhibitor with an inhibition constant (Ki value) of 61 μM [2].
7-Methylguanine (0-450 μM) suppresses the catalytic activity of PARP-1, thereby preventing the dissociation of the PARP-1-DNA complex [2].
After 24 hours of treatment with 7-Methylguanine (0.02-0.2 mg/mL), no DNA damage was observed in immortalized Homo sapiens renal epithelial cells (NKE-hTERT) [3]. |
| In vivo | In CBA, BALB/c, and C57BL/6 mice, 7-Methylguanine (50 mg/kg, administered orally, three times per week for 4 weeks) did not cause adverse reactions or morphological changes, while it inhibited tumor growth in CBA mice with uterine sarcoma US-322 [3].
In BALB/c mice transplanted with Akatol tumors, 7-Methylguanine (50 mg/kg, administered via gavage, three times per week) effectively penetrated tumor tissues and suppressed the growth of colon adenocarcinoma [5]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 1M NaOH : 80 mg/mL (484.41 mM), Sonication is recommended.
H2O : 3.3 mg/mL (19.98 mM), when pH is adjusted to 11 with 1 M NaOH. Sonication is recommended.
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| Keywords | Human Endogenous Metabolite | 7-Methylguanine | 7Methylguanine | 7 Methylguanine |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Human Metabolite Library | Anti-Cancer Active Compound Library |
United States
