| Name | 8-Geranyloxypsoralen |
| Description | 8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg/ L against B. xylophilus and is 117.5 mg/L against P. redivivus. |
| In vitro | Through bioassay-guided fractionations, three coumarins were obtained from the extract of H. candicans and determined to be 8-Geranyloxypsoralen (1), imperatorin (2), and heraclenin (3) based on spectra data. All three compounds possessed nematicidal activities against the two tested nematodes. The median lethal concentrations (LC(50)) of compounds 1-3 at 72 h were 188.3, 161.7, and 114.7 mg L(-1) respectively against B. xylophilus and were 117.5, 179.0, and 148.7 mg L(-1) respectively against P. redivivus[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45.00 mg/mL (132.98 mM), Sonication is recommended. 10% DMSO+90% Corn Oil : 2 mg/mL (5.91 mM), Sonication is recommended.
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| Keywords | P450 | Inhibitor | inhibit | Cytochrome P450 | CYPs | BACE | Anti-infection | Antiinfection | Antifection | 8-Geranyloxypsoralen | 8Geranyloxypsoralen | 8 Geranyloxypsoralen |
| Inhibitors Related | Oxadiazon | Musk ketone | Naringin dihydrochalcone | Ipriflavone | Benzyl alcohol | Sudan IV | Penicillin G potassium | (E)-3-(p-Tolyl)acrylaldehyde | Naringin | Chlorzoxazone | Dibenzothiophene | Clarithromycin |
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