| Name | 8-iso-13,14-dihydro-15-keto Prostaglandin F2α |
| Description | 8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits. Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF2α was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF2α weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | PBS (pH 7.2) : >10 mg/mL (from PGF2a), Sonication is recommended.
10 mM Na2CO3 : >6.5 mg/mL (from PGF2a), Sonication is recommended.
Ethanol : >100 mg/mL (from PGF2a), Sonication is recommended.
DMSO : >100 mg/mL (from PGF2a), Sonication is recommended.
DMF : >100 mg/mL (from PGF2a), Sonication is recommended.
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| Keywords | 8-iso-13,14-dihydro-15-keto Prostaglandin F-2α | 8iso13,14dihydro15keto Prostaglandin F2α | 8-iso-13,14-dihydro-15-keto Prostaglandin F2alpha | 8-iso-13,14-dihydro-15-keto Prostaglandin F2a | 8 iso 13,14 dihydro 15 keto Prostaglandin F2α |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
United States
