| Name | AA26-9 |
| Description | AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase. |
| Cell Research | AA26-9 is prepared in DMSO. Cells are cultured with 20 μM inhibitor AA26-9 or DMSO as a control for 4 h, lysed, separated into soluble and analyzed by competitive gel-based ABPP[1]. |
| In vitro | AA26-9 inhibits enzymes originated from diverse functional subclasses of serine hydrolases, including peptidases (APEH, CTSA, PRCP), thioesterases (LYPLA1/2), lipases/phospholipases (AADACL1, ESD, ABHD6, PAFAH2, FAAH, LYPLA3), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (330.97 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (12.04 mM), Sonication is recommended.
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| Keywords | thioesterases | SerineProtease | Serine Protease | serine hydrolase | serine | Phospholipase | peptidases | lipases | Inhibitor | inhibit | esterases | cell | amidases | AA26-9 | AA-26-9 | AA269 | AA26 9 |
| Inhibitors Related | Neomycin sulfate | Levamisole hydrochloride | Difluprednate | AEBSF hydrochloride | Imidazole | Subtilisin | Chymotrypsin | Proteinase K | Ac-Ala-OH | Trypsin | Lansoprazole | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | Anti-Obesity Compound Library | Protease Inhibitor Library | Multi-Target Compound Library | Inhibitor Library | NO PAINS Compound Library | Lipid Metabolism Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |