| Name | Abaperidone |
| Description | Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound that reduces basal hsp70 mRNA expression in rat striatum and prefrontal cortex. expression in the striatum and prefrontal cortex of rats. |
| In vitro | Abaperidone exhibits a strong binding affinity for dopamine D2 receptors, as well as a higher affinity for 5-HT2 receptors, with IC50 values of 17 and 6.2 nM, respectively.[1] |
| In vivo | After oral administration of either 0.5 mg/kg of Abaperidone or risperidone, the time course of the inhibition of climbing behavior for a period of several hours is tested in mice.[1]
In a study of serum prolactin levels after oral administration of Abaperidone and haloperidol, the prolactin levels of risperidone at 5 mg/kg for either 1 or 3 days in rats, showing the prolactin levels increased in smaller than those for reference drugs. A lesser induction of catalepsy is observed for Abaperidone.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 1.46 mg/mL (3.23 mM), Sonication is recommended.
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| Keywords | DopamineReceptor | Dopamine Receptor | D2 Receptor | Abaperidone | 5HTReceptor | 5-HT2A Receptor | 5-HT2A | 5HT Receptor |
| Inhibitors Related | Trifluoperazine dihydrochloride | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | Octopamine hydrochloride | 1,8-Cineole | L-DOPA | Creatine | Oxolinic acid | Mianserin hydrochloride | Trazodone hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Angiogenesis related Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library |
United States
