| Name | ABC1183 |
| Description | ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, β-catenin phosphorylation and MCL1 expression,and is orally active. |
| In vitro | ABC1183 inhibits cell proliferation and tumor growth of various cancer types by specifically attenuating GSK3 and CDK9 activity. ABC1183 altered GSK3 activity as indicated by decreased GSK3α/β and GS phosphorylation and increased β-catenin phosphorylation[1]. |
| In vivo | Murine melanoma B16 tumors were propagated in C57BL/6 mice were treated with oral ABC1183 or vehicle. Tumor growth was decreased more than 70% within 8 days by ABC1183 treatment. On the basis of body weight, gross toxicities were not observed. ABC1183 was determined to suppress tumor growth in the absence of organ and hematopoietic toxicity. The expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) were suppressed[1][2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.35 mg/mL (10.02 mM), Sonication is recommended.
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| Keywords | GSK-3β | GSK-3α | GSK3 | CDK9/cyclin T1 | ABC1183 |
| Inhibitors Related | Ribociclib | Amantadine | 2-Chloropyrazine | Kojic acid | Cromolyn sodium | Abemaciclib | 4-Chloro-2'-bromoacetophenone | Ethyl linoleate | 2,4,6-Trihydroxybenzoic acid | Palbociclib | (E/Z)-10-Hydroxy-2-decenoic acid | Sodium Oxamate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Hematonosis Compound Library | Neuroprotective Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Active Compound Library | Neuronal Differentiation Compound Library |
United States
