| Name | Acarbose |
| Description | Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity. |
| Cell Research | Cell viability is determined using the MTT assay. Cells are seeded in 24-well culture plates at a density of 2×104 cells/well, incubated for 48 h, treated with acarbose at varying concentrations (0.5, 1.0, 2.0, 3.0, and 5.0 μM) for 24 h; or pre-treated with TNF-α (20 ng/mL) for either 24 h or 48 h to evaluate the dose-dependent effects of acarbose on VSMC growth and viability, cultured with 0.5 mg/mL MTT at 37°C in a humidified atmosphere of 5% CO2 for another 4 h, and solubilized with isopropanol. The viable cell number varies directly with the concentration of formazan product measured spectrophotometrically at 563 nm. |
| In vitro | Acarbose binds to and inhibits α-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides and disaccharides into glucose and other monosaccharides. In addition, acarbose inhibits pancreatic α-amylase which hydrolyzes complex starches to oligosaccharides in the small intestines. |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (77.45 mM), Sonication is recommended.
H2O : 64.5 mg/mL (99.91 mM), Sonication is recommended.
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| Keywords | α-glucosidase | oral | mellitus | insulin | Inhibitor | inhibit | Glucosidase | BAY g-5421 | BAY g5421 | antihyperglycemic | anti-diabetes | Acarbose |
| Inhibitors Related | α-Glucosidase-IN-23 | 1-Deoxynojirimycin | Conduritol B epoxide | NCGC00092410 | Voglibose | Pinoresinol diglucoside | N-Caffeoyl O-methyltyramine | Rebaudioside A | (E)-3-(4-Methoxyphenyl)acrylic acid | Naringinase | IHVR-17028 | 3-Butylidenephthalide |
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United States
