| Name | Acemetacin |
| Description | Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin and a potent non-steroidal anti-inflammatory drug derived from indol-3-acetic acid, with its activity primarily attributed to its active metabolite, indomethacin. In clinical trials, acemetacin shows better gastric tolerability compared to indomethacin. |
| In vitro | In rats pre-treated with COX-2 and NOS inhibitors, despite significant inhibition of COX activity, Acemetacin significantly reduces gastrointestinal damage compared to Indomethacin. |
| In vivo | Acemetacin exerts its anti-inflammatory effect by inhibiting the synthesis of prostaglandins (PG). In inflamed synovial tissue, Acemetacin (10 μM) prevents the release of Prostaglandin E2 (PGE2). It inhibits the release of prostaglandin E2 in joint synovial tissues in vitro. During the incubation of gastric mucosa, the concentration-dependent inhibition of PGE accumulation by Acemetacin is not as effective as Indomethacin, and its reduction effect on gastric 6-keto-PGF1α and thromboxane B2 is also lower than that of Indomethacin. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 77 mg/mL (185.18 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.81 mM), Sonication is recommended.
Ethanol : 54 mg/mL (129.86 mM), Sonication is recommended.
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| Keywords | TVX-1322 | TVX1322 | K708 | K 708 | Inhibitor | inhibit | Cyclooxygenase | COX | Acemetacin |
| Inhibitors Related | Naproxen sodium | Acetaminophen | Phenidone | 4-Aminosalicylic acid | Gallic Acid Monohydrate | Diclofenac Potassium | Indomethacin | Paradol | Trometamol | 5-Methylfurfural | Phenylbutazone | Magnesium sulfate |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Drug Repurposing Compound Library | Anti-Fibrosis Compound Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | NMPA-Approved Drug Library | Anti-Cancer Drug Library |
United States
