| Name | Adapalene |
| Description | Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions. |
| In vitro | In rhino mice, Adapalene reduces the quantity of comedonal melanin in the epidermis and increases epidermal thickness. Within both normal skin and acne explants, Adapalene decreases the expression of TLR-2 (TLR-2) and IL-10 (IL-10). By upregulating CD1d expression and downregulating the IL-10 expression in keratinocytes, Adapalene modulates the epidermal immune system. This action enhances the interaction between dendritic cells and T lymphocytes, augmenting antimicrobial activity against Propionibacterium acnes. |
| In vivo | In colorectal cancer cell lines CC-531, HT-29, and LOVO, as well as in human foreskin fibroblasts, Adapalene induces caspase-3 activity in tumor cells, inhibits DNA synthesis in a time- and dose-dependent manner, and triggers apoptosis. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 12.5 mg/mL (30.3 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 1 mg/mL (2.42 mM), Sonication is recommended.
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| Keywords | tumor | RXR | RetinoidReceptor | Retinoid X receptors | Retinoid Receptor | retinoid | Retinoic acid receptors | RARγ | RARβ | RARα | RAR/RXR | RAR | Inhibitor | inhibit | GOT1 | CD-271 | CD 271 | Autophagy | Apoptosis | Adapalene | acne |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Cancer Cell Differentiation Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
