Ademethionine 1,4-Butanedisulfonate NEW

Treatment of intrahepatic cholestasis: This is its core clinical application. It is widely used for intrahepatic cholestasis caused by pre - cirrhosis and cirrhosis. In the liver, it regulates the fluidity of the liver cell membrane by methylating plasma membrane phospholipids. Meanwhile, through transsulfuration reactions, it promotes the synthesis of sulfide products in the detoxification process, thereby improving the bile excretion function of the liver and alleviating symptoms such as jaundice and pruritus caused by cholestasis. It is also applicable to intrahepatic cholestasis during pregnancy, and it is safe for pregnant and lactating women to use under the guidance of doctors.

Adjunctive treatment of depression: It can participate in the synthesis of neurotransmitters such as norepinephrine and melatonin in the body. Some studies have shown that it is effective in treating mild to moderate depression. Compared with traditional antidepressants, it may take effect faster and has fewer side effects such as headaches and sleep disorders. However, when used for treating depression, close monitoring is required, especially for patients with a history of suicidal thoughts, to prevent the risk of suicidal behavior.

Relief of osteoarthritis symptoms: Relevant studies have confirmed that this compound can reduce joint pain and inflammation in patients with osteoarthritis. It can also promote cartilage repair, and is comparable to non - steroidal anti - inflammatory drugs in relieving morning stiffness, reducing joint swelling, and improving joint mobility. Moreover, it has better tolerance and fewer side effects, making it a potential adjuvant therapeutic drug for osteoarthritis.

Adjunctive improvement of fibromyalgia: In some clinical studies, it has been found to help alleviate symptoms of fibromyalgia, including general body pain, persistent fatigue, morning stiffness, and accompanying depressed mood. Most of the early effective studies adopted the injection form of this drug, and the relevant research on oral dosage forms is still being supplemented and improved.

Research on stable forms of SAM - e: As a stable salt form of SAM - e, it effectively solves the problem that free SAM - e is prone to oxidative degradation during storage and transportation. It is often used as a research object in pharmaceutical research to explore the optimization of stable forms of bioactive molecules and provide a reference for the development of related preparations.

Study on related metabolic pathways: It serves as a key methyl donor and precursor of physiological sulfhydryl compounds in cells. In biochemical experiments, it can be used to study the mechanisms of intracellular transmethylation, transsulfuration, and decarboxylation reactions, as well as the role of these metabolic pathways in maintaining the normal physiological functions of the liver, nervous system, and other organs.

Pharmaceutical preparation compatibility research: It is also a common research subject in the compatibility stability of pharmaceutical preparations. For example, researchers have studied its stability when mixed with fructose and glucose injection diluents. Such research is of great significance for guiding the rational clinical use of the drug, avoiding drug efficacy reduction or adverse reactions caused by improper compatibility.