| Name | ADH-503 |
| Description | ADH-503 (GB1275) is an orally available, allosteric CD11b small molecule agonist that can lead to repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhancement of dendritic cell responses. |
| Animal Research | Animal Model:Male rats.Dosage:30,100 mg/kg (Pharmacokinetic Analysis). Administration:Oral gavage twice a day; on days 1 and 5 |
| In vitro | METHODS: ADH-503 (GB1275) (4 μM, 10 days) was used to investigate the expression of macrophage markers in two syngeneic orthotopic models.
RESULTS After treatment with ADH-503 (GB1275), macrophages expressed higher levels of MHCI, MHCII, CD80, and CD86, indicating improved antigen presentation properties of the remaining macrophages. [1] |
| In vivo | METHODS: ADH-503 (GB1275) (30, 100 mg/kg, oral) was administered to rats and C57/B6 mice to test the pharmacokinetics (PK) and safety.
RESULTS The mean half-life of ADH-503 (GB1275) in rats and mice after administration was 4.68 and 3.95 hours, and the Cmax and AUC0-t in plasma were 1716 and 2594 ng/mL and 6950 and 13962 ng.h/mL, respectively. [1] |
| Storage | 02 | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5.25 mg/mL (10.01 mM), Sonication is recommended.
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| Keywords | tumor-infiltrating | tumorassociated | repolarization | orally | macrophages | Inhibitor | inhibit | immunosuppressive | GB-1275 | GB 1275 | dendritic | ComplementSystem | Complement System | CD11b | allosteric | ADH-503 | ADH503 | ADH 503 |
| Inhibitors Related | Iptacopan hydrochloride | Tirofiban hydrochloride monohydrate | Iptacopan | Cyclo(-RGDfK) | Dexamethasone acetate | Dexamethasone | CLT-28643 | Bestatin hydrochloride | Cyclosporin A | Dextran sulfate sodium salt (MW 5000) | 3-Phenoxybenzaldehyde | 2-hydroxy Flutamide |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
