Chinese name: Afatinib
English name: Afatinib
CAS: 850140-72-6
Molecular formula: C24H25ClFN5O3
Molecular weight: 485.938
category
API: Tinib antitumor drugs
Melting point: 102 °C
Boiling point: 676.9±55.0 °C(Predicted)
Density: 1.380
Storage condition: -20°C
Solubility: Soluble in DMSO (up to 25mg/ml) or ethanol (up to 25mg/ml).
Acidity coefficient (pKa) : 11.79±0.43(Predicted)
Form: Yellow powder
Color: Light yellow
Stability: Can be stored in DMSO or ethanol solution at -20°C for up to 2 months.
use
Afatinib is an amino-crotonyl amino substituted quinazoline derivative that can be used to treat cancers and diseases of the respiratory tract, lung, gastrointestinal, bile duct and gallbladder. Afatinib has also been selected for use in several tumor classes and is currently undergoing advanced clinical trials in head and neck cancer.