| Name | Aftin-4 |
| Description | Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain. |
| Animal Research | Brains of 4-mo-old C57BL/6 wild-type mice were dissected and mechanically disassociated in HBSS with a tissue homogenizer. Aliquots from each mouse were incubated with DMSO and two concentrations of Aftin-4 at 37°C for 3 h. Liquefied brains were sonicated and centrifuged at 13,000 rpm for 15 min. WB analysis was performed using CT695 antibody for soluble Aβ-CTF. They are for reference only. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.43 mM), Sonication is recommended.
DMSO : 55 mg/mL (149.26 mM), Sonication is recommended.
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| Keywords | γ secretase(Aβ42) | β-amyloid peptide | βAmyloid | β Amyloid | Inhibitor | inhibit | Gammasecretase | BetaAmyloid | Beta Amyloid | bAmyloid | b Amyloid | Amyloid-β | Aftin-4 | Abeta |
| Inhibitors Related | Benzenesulfonamide | Deferoxamine Mesylate | HEPPS | Phytic acid sodium salt | Rutin | Resveratrol | Valproic Acid | 10-Undecenoic acid | 2,4-Di-tert-butylphenol | Chlorzoxazone | Prednisone acetate | Methyl tridecanoate |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Protease Inhibitor Library | Multi-Target Compound Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | Bioactive Compounds Library Max |
United States
