| Name | Agomelatine (L(+)-Tartaric acid) |
| Description | Agomelatine (L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2), and Agomelatine (S-20098). L(+)-Tartaric acid also functions as a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native porcine and cloned human 5-HT2C receptors), actively supporting research into melatonergic signaling pathways, receptor-mediated regulation, and novel psychiatric therapeutics by enabling precise modulation of circadian and serotonergic systems in cellular models to improve neuropharmacological understanding and experimental reproducibility across neuroscientific and clinical translational studies. |
| In vitro | In the experimental system where human MT1 receptors (hMT1) and human MT2 receptors (hMT2) are expressed on the cell membranes of CHO cells (or HEK cells), the EC₅₀ values of Agomelatine (L(+)-Tartaric acid) acting on CHO-hMT1 and CHO-hMT2 are 1.6±0.4 nM and 0.10±0.04 nM, respectively[1]. |
| In vivo | Agomelatine (L(+)-Tartaric acid) (25, 50, or 75 mg/kg, intraperitoneal injection) exhibits antioxidant activity in strychnine- or pilocarpine-induced seizure models in mice. However, compared with the control group, Agomelatine (L(+)-Tartaric acid) did not demonstrate any antioxidant effects on oxidative stress-related indicators in pentylenetetrazole (PTZ)- or picrotoxin (PTX)-induced seizure models [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (203.36 mM), Sonication is recommeded.
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| Keywords | S-20098 LTartaric acid | native porcine 5-HT2C receptor | human 5-HT2C receptor | HEK-hMT2 | HEK-hMT1 | CHO-hMT2 | CHO-hMT1 | Agomelatine (LTartaric acid) | Agomelatine (L(+)Tartaric acid) | Agomelatine (L(+) Tartaric acid) | 5HTReceptor | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | 1,8-Cineole | glycine | Dopamine hydrochloride | Cloperastine hydrochloride | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine | Doxepin hydrochloride |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Neuronal Signaling Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library |
United States
