| Name | Ajmalicine |
| Description | Ajmalicine (Raubasine) (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, IC50 = 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity. |
| In vitro | Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor[1]. Ajmalicine inhibits contractions in a concentration-dependent manner, IC50=72.3 ± 22.5 μM[2]. Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[3]. |
| In vivo | Ajmalicine blocks the pressor action of electrical stimulation and is active against sympathetic stimulation. Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 2.5 mg/mL (7.09 mM), Sonication is recommended.
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| Keywords | Δ-Yohimbine | α1-adrenoceptor | Ajmalicine | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Ethyl (triphenylphosphoranylidene) acetate | Methylene Violet 3RAX | 4-Methylbenzylidene camphor | Octopamine hydrochloride | Diethyltoluamide | Isoprenaline hydrochloride | Propoxur | Dimethyl sulfoxide | Coumaran | D-Mannitol | Methyl tridecanoate | Trimethylammonium chloride |
| Related Compound Libraries | Terpene Natural Product Library | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Drug Repurposing Compound Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
United States
