| Name | alpha-Mangostin |
| Description | alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree. |
| Cell Research | IDH1+/+ and IDH1 |
| In vitro | Alpha-mangostin exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. Alpha-mangostin competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-mangostin exhibits the strongest core inhibitor structure. Alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells[1]. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP)[2]. Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM Water2-induced apoptosis of RPE cells. 200 μM Water2-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-mangostin[3]. |
| In vivo | Alpha-mangostin mitigates the risk of liver fibrosis by diminishing p53 expression relative to TAA_DMSO treatment. Moreover, following α-mangostin administration, serum concentrations of liver enzymes AST and ALT are reduced in comparison to treatment with DMSO alone[4]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 2 mg/mL (4.87 mM), Sonication is recommended.
DMSO : 252.5 mg/mL (615.16 mM), Sonication is recommended.
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| Keywords | VirusProtease | Virus Protease | ReactiveOxygenSpecies | Reactive Oxygen Species | Inhibitor | inhibit | IDH1-R132H | Fungal | Bacterial | Apoptosis | a-Mangostin | alpha-Mangostin | alphaMangostin | alpha Mangostin |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Aceglutamide | D(+)-Raffinose pentahydrate | Benzyl propionate | Ethyl linoleate | Formamide | Thymidine | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Tobacco Monomer Library | Inhibitor Library | Anti-Aging Compound Library | Anti-virus Traditional Chinese Medicine Monomer Library | Anti-Cancer Drug Library | Food as Medicine Compound Library |
United States
