| Name | Alvelestat |
| Description | Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity. |
| In vitro | In a mouse model of (smoke)-induced airway inflammation, AZD9668 significantly reduced the number of (neutrophils) in the bronchoalveolar lavage (BAL) and the level of BAL IL-1β. Oral administration of AZD9668 in both mice and rats was able to inhibit (NE)-induced lung injury. |
| In vivo | In whole blood stimulated by yeast polysaccharide, AZD9668 effectively inhibits NE (NE) activity in the supernatant of antigen-challenged cells and on the surface of stimulated polymorphonuclear cells. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 40 mg/mL (73.32 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.67 mM), Sonication is recommended.
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| Keywords | SerineProtease | Serine Protease | neutrophil elastase | Inhibitor | inhibit | Elastase | AZD-9668 | AZD 9668 | Alvelestat |
| Inhibitors Related | PMSF | AEBSF hydrochloride | Imidazole | Subtilisin | p-Aminobenzamidine dihydrochloride | Chymotrypsin | Proteinase K | Aprotinin | Ac-Ala-OH | Trypsin | FOY 251 | Benzamidine hydrochloride |
| Related Compound Libraries | Highly Selective Inhibitor Library | Bioactive Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Inhibitor Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Metabolism Disease Compound Library | Human Metabolite Library |