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ChemicalBook Product Catalog Biochemical Engineering Inhibitors protein tyrosine kinase AMG-208

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AMG-208 NEW

$55.00 5mg

$84.00 10mg

$152.00 25mg

Min. Order
Purity99.27%
Cas No1002304-34-8
Supply Ability10g
Update time2026-04-14

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	AMG-208
CAS No	1002304-34-8
EC-No
Min. Order
Purity	99.27%
Supply Ability	10g
Release date	2026/04/14

Product Introduction

Bioactivity

Name	AMG-208
Description	AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.
In vitro	AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM. [1] Incubation of AMG-208 with rat and human liver microsomes in the presence of NADPH qualitatively yields C6-phenylarene oxidation products as the major metabolites. [1] Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation. [2] AMG-208 is identified to be a c-MET and RON dual selective inhibitor. [3]
In vivo	In male Sprague?Dawley rats, AMG-208 (0.5 mg/kg i.v.) shows a high bioavailability with Cl of 0.37 L/h/kg, Vss of 0.38 L/kg and T1/2 of 1 hour, while AMG-208 (2 mg/kg i.v.) shows a bioavailability with AUC0→∞ of 2517 ng·h/mL and F of 43%, respectively. [1]
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 2.5 mg/mL (6.52 mM), Sonication is recommended.
Keywords	Inhibitor \| inhibit \| HGFR \| Cytochrome P450 \| CYPs \| c-Met/HGFR \| cMet/HGFR \| c-Met \| cMet \| AMG-208 \| AMG208
Inhibitors Related	Oxadiazon \| Musk ketone \| Naringin dihydrochalcone \| Decanoic Acid \| Ipriflavone \| Benzyl alcohol \| Sudan IV \| Naringin \| Chlorzoxazone \| Dibenzothiophene \| Clarithromycin \| Memantine hydrochloride
Related Compound Libraries	Target-Focused Phenotypic Screening Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Tyrosine Kinase Inhibitor Library \| Kinase Inhibitor Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Active Compound Library \| Anti-Cancer Drug Library

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