| Name | Amikacin disulfate |
| Description | Amikacin disulfate (BAY-416651 sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A. |
| In vitro | Amikacin sulfate has high affinities for 16S rRNA of the bacterial 30S ribosome, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. [1] Amikacin is active in vitro against Pseudomonas species, [2] Escherichia coli[3], Proteus species (indole-positive and indole-negative), Providencia species, Klebsiella-Enterobacter-Serratia species, Acinetobacter (formerly Mima-Herellea) species, and Citrobacter freundii.[4] [5] In vitro studies have shown that amikacin sulfate combined with a beta-lactam antibiotic acts synergistically against many clinically significant Gram-negative organisms. In vitro studies have shown that amikacin sulfate combined with beta-lactam antimicrobial agents including moxalactam or piperacillin acts synergistically against many clinically significant Gram-negative organisms. [6] |
| In vivo | Amikacin (80 mg/kg i.v.) significantly reduced pseudomonal densities within aortic vegetations compared to controls in the experimental rabbit endocarditis model. In addition, amikacin given once daily is still more effective than the twice-daily regimen. [7] Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity in model of Mycobacterium avium complex infections in beige mice. Addition of clofazimine increased the activity significantly. [8] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL (127.92 mM), Sonication is recommended.
DMSO : Insoluble
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| Keywords | synthesis | ribosomal | protein | ototoxic | kanamycin | Inhibitor | inhibit | infections | Gram-negative | BAY-416651 Sulfate | BAY416651 Sulfate | BAY 416651 Sulfate | BAY 41-6551 disulfate | Bacterial | bacillary | Antimicrobial | Antibiotic | aminoglycosides | Amikacin Sulfate | Amikacin disulfate | Amikacin | 16S rRNA |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
| Related Compound Libraries | Approved Drug Library | EMA Approved Drug Library | Anti-Gram-Negative Bacterial Library | Drug Repurposing Compound Library | Anti-Bacterial Compound Library | Immunology/Inflammation Compound Library | Anti-Infection Compound Library | NMPA-Approved Drug Library |
United States
