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ChemicalBook Product Catalog Chemical Reagents Organic reagents Hydroxylamine Aminooxyacetic acid hemihydrochloride

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Aminooxyacetic acid hemihydrochloride NEW

$ 41.00 /500mg

Min. Order
Purity98.03%
Cas No2921-14-4
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	Aminooxyacetic acid hemihydrochloride
CAS No	2921-14-4
EC-No
Min. Order
Purity	98.03%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	Aminooxyacetic acid hemihydrochloride
Description	Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride) is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
In vivo	At various intervals after aminooxyacetic acid(AOAA) the rats were either injected with one of the convulsive drugs or sacrificed for analysis of the GABA concentration.?AOAA caused a rapid initial (0-30 min) and a later slower increase of GABA in cerebellum and whole brain.?In the synaptosomal fraction the GABA accumulation was delayed and less pronounced when compared to the whole brain.?The bicuculline induced convulsions were markedly potentiated during the first hour but completely blocked from 2-6 h after AOAA.?Picrotoxin showed a somewhat different pattern to bicuculline in the interactions with AOAA.?The initial strong potentiation was not observed but the later phase of protection was present.?In the interactions with 3-MPA, the effect of AOAA was always protective.?The time to onset of convulsions was gradually increased during the first 30 min after AOAA.?This protective effect remained practically unchanged up to 6 h after AOAA.?However, once started, the convulsions were generally of the same duration and intensity.?The results can be interpreted as GABA accumulating after AOAA stimulates GABA receptors to a degree more or less proportional to the whole brain GABA concentration and further that GABA synthetized in neurons is liberated, stimulates inhibitory bicuculline sensitive (predominant) and excitatory bicuculline insensitive receptors and is captured to a large extent by non-neuronal cells[1].
Storage	Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO : 250 mg/mL (2287.28 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (18.3 mM), Sonication is recommended.
Keywords	γ-Aminobutyric acid Receptor \| MAS \| Inhibitor \| inhibit \| Gamma-aminobutyric acid Receptor \| GABAReceptor \| GABA Receptor \| GABA \| Carboxymethoxylamine \| Aminooxyacetic acid hemihydrochloride \| Aminooxyacetic acid \| Aminooxyacetate hemihydrochloride
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