| Name | Ampicillin |
| Description | Ampicillin (Aminobenzylpenicillin) is a semi-synthetic penicillin belonging to the β-lactam group of antibiotics. Ampicillin has bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria. |
| In vitro | METHODS: E. coli was treated with Ampicillin (0.1-10 μG/mL) for 6 h. Growth was measured using a Fisher Electrophotometer.
RESULTS: No differences in E. coli growth were observed at concentrations of 0, 0.1, and 1.0 μG. 2.5, 5, and 10 μG concentrations of Ampicillin inhibited E. coli growth. [1]
METHODS: Pharyngeal cancer cells Detroit-562 were treated with Ampicillin (10-100 μM) for 72 h. Cell viability was measured by MTT.
RESULTS: The Ampicillin-treated groups at concentrations of 10, 25 and 50 μM showed higher cell viability than the control cells, with values of 112%, 107% and 106%, respectively. At concentrations of 75 and 100 μM, there was a slight but not significant decrease in cell viability with values of approximately 95% and 94%, respectively. [2] |
| In vivo | METHODS: To test the neuroprotective mechanism in a mouse model of transient total forebrain ischemia, Ampicillin (200 mg/kg) was injected intraperitoneally into C57BL/6 mice once a day for five days, and forebrain ischemia was induced 24 h after the last injection.
RESULTS: Pretreatment with Ampicillin significantly attenuated neuronal damage in the CA1 subregion of the hippocampus, and Ampicillin may provide neuroprotection against cerebral ischemia/reperfusion injury by inducing GLT-1 protein and inhibiting MMP activity in the hippocampus of mice. [3]
METHODS: To study the in vivo activity, Ampicillin (10-100 mg/kg) was administered by gavage to C57BL/6 mice once daily for two days.
RESULTS: Exposure of mice to Ampicillin induced anxiety and colitis, and increased Aspergillus flora in the gut microbiota. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 22.5 mg/mL (64.4 mM), Sonication is recommended.
0.1 M NaOH : 25 mg/mL (71.55 mM), Sonication is recommended.
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| Keywords | PBPs | D-α-Aminobenzylpenicillin | D-alpha-Aminobenzylpenicillin | D-a-Aminobenzylpenicillin | Bacterial | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Doxycycline (hyclate) | Kanamycin sulfate | Urethane | Sulfamethoxazole sodium | Doxycycline | EDTA copper(II) disodium salt | Isoeugenol | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Natural Product Library | Beta-Lactam Compound Library | Microbial Natural Product Library | FDA-Approved Drug Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bitter Compound library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |
United States
