| Name | Ampyrone |
| Description | Ampyrone (4-Aminoantipyrine) is a reagent for glucose determination in the presence of peroxidase and phenol. |
| Cell Research | Erythrocytes in PBS are incubated for 2 h at ambient temperature (without mixing) with AAP in concentrations from 1 × 10−6 mol/L to 1 × 10−3 mol/L. Sample of erythrocytes without AAP is used as control. After the exposure of AAP, erythrocytes are washed with borate buffer (pH 9.0) 2 times by centrifuging and determined for GSH. (Only for Reference) |
| In vitro | The level of glutathione(GSH) in single erythrocytes is impacted slightly at low AAP(4-aminoantipyrine) concentrations probably due to the protection of glutathione reductase. When AAP concentration further increases, AAP has a significant influence on GSH[2]. |
| In vivo | 4-aminoantipyrine (4-AA) is not genotoxic and mutagenic in vivo, it can interfere with DNA damaging agents biological activities and may reduce the effectiveness of DNA damage-based chemotherapy[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 40 mg/mL (196.81 mM), Sonication is recommended.
H2O : 37 mg/mL (182.05 mM), Sonication is recommended.
DMSO : 74.29 mg/mL (365.53 mM)
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| Keywords | NSC-60242 | NSC60242 | Inhibitor | inhibit | DrugMetabolite | Drug Metabolite | Cyclooxygenase | COX | Ampyrone |
| Inhibitors Related | Naproxen sodium | 2-(Methylamino)benzoic acid | Acetaminophen | Phenidone | 10-Undecen-1-ol | Gallic Acid Monohydrate | Diclofenac Potassium | Indomethacin | Paradol | Trometamol | 5-Methylfurfural | Magnesium sulfate |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Approved Drug Library | Drug Repurposing Compound Library | NO PAINS Compound Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Human Metabolite Library | Anti-Cancer Drug Library |
United States
