It is the main component of amyloid plaques and accumulates in the brain neurons of Alzheimer's disease patients. Aβ peptides and their peptide fragments as well as mutant fragments are used to study various metabolic and regulatory functions, including kinase activation, cholesterol transport regulation, transcription factor function, and inflammation regulation. Aβ peptides and their peptide fragments are also used to study oxidative stress, metal binding, and protein cross-linking mechanisms in Alzheimer's disease and neurodegenerative disorders.
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