| Name | Anandamide |
| Description | Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous system. |
| In vitro | Anandamide, acting via CB2 receptors, alleviates lipopolysaccharide (LPS)-induced neuroinflammation in rat primary microglial cultures. Endocannabinoids, especially Anandamide (AEA), can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55 [1]. |
| In vivo | Anandamide is an endocannabinoid binding both CB1R and CB2R. To evaluate the impact of CBR activation on whole-body glucose homeostasis, glucose tolerance is assessed after a single intraperitoneal Anandamide injection (10 mg/kg). The increase in glycemia in response to glucose ingestion is considerably smaller in mice treated with Anandamide compared with control. It is associated with an improvement of glucose tolerance as illustrated by the AUC0-2h calculations[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 10 mg/mL (28.77 mM), Sonication is recommended.
DMSO : 55 mg/mL (158.26 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.75 mM), Sonication is recommended.
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| Keywords | TRP Channel | Transient receptor potential channels | Tau Protein | Streptozotocin | PPAR | Peroxisome proliferator-activated receptors | N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide | Inhibitor | inhibit | hVSMC | Human Endogenous Metabolite | HeLa cells | GPR55 | GPR18/GPR55 | G protein-coupled receptor 55 | Fungal | EndogenousMetabolite | Endogenous Metabolite | endocannabinoid | cervical epithelial cells | CB2 | CB1 | CannabinoidReceptor | Cannabinoid Receptor | Candida albicans | anti-fungal | anti-adhesive | Anandamide | Alzheimer's disease |
| Inhibitors Related | Sucrose | Calcium Propionate | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Benzyl propionate | Malic acid | Glycerol | Thymidine | Gluconate Calcium |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Anti-Fungal Compound Library | Natural Product Library | Natural Product Library for HTS | Human Endogenous Metabolite Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
United States
