Product Name: Anastrozole
Brand Name: Arimidex
CAS Number: 120511-73-1
Molecular Formula: C17H19N5
Molecular Weight: 293.37 g/mol
Appearance: White to off-white solid
Description:Anastrozole is a potent and selective third-generation aromatase inhibitor. It works by reducing the amount of estrogen the body produces, which can help slow or reverse the growth of certain breast cancers that require estrogen to grow.
Mechanism of Action:Anastrozole inhibits the enzyme aromatase, which is responsible for the conversion of androgens to estrogens in postmenopausal women. By inhibiting this enzyme, Anastrozole significantly lowers circulating estrogen levels, depriving the tumor of this growth-promoting hormone.
Pharmacological Properties:
Aromatase Inhibition: Highly effective in inhibiting the aromatase enzyme.
Breast Cancer Treatment: Indicated for the treatment of early-stage and advanced breast cancer in postmenopausal women with hormone receptor-positive tumors.
Clinical Uses:
Adjuvant Treatment: Used after surgery to reduce the risk of breast cancer recurrence.
First-Line Therapy: For postmenopausal women with locally advanced or metastatic breast cancer.
Second-Line Therapy: For those with disease progression following treatment with tamoxifen.
Pharmaceutical Applications:
Safety and Precautions:
Contraindications: Not recommended for use in premenopausal women or men.
Warnings: May decrease blood flow to the heart; caution is advised in patients with a history of coronary artery disease.
Pregnancy and Lactation: Not to be used during pregnancy or breastfeeding.
Pharmacokinetics:
Absorption: Rapidly absorbed after oral administration.
Distribution: Low plasma protein binding.
Metabolism: Extensively metabolized in the liver.
Excretion: Primarily eliminated in the feces, with a smaller portion in urine.
Storage Conditions:
Packaging:
Manufacturing and Quality Control:
Environmental Considerations:
China
