| Name | Ara-G |
| Description | Ara-G is a deoxyguanosine (GdR) analog and a nucleoside analogue that is rapidly converted by cells of the T lymphoid lineage to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and selective in vitro toxicity to T lymphoblastoid cell lines as well as to freshly isolated leukemia cells from patients with T cell acute lymphoblastic leukemia (ALL). |
| In vitro | Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.3,1 Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 μM in CEM cells, which are used as a model for human T lymphoblasts.1 It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.3 Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.4 |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : Partially Soluble
DMF : 3 mg/mL (10.59 mM), Sonication is recommended.
DMSO : 55 mg/mL (194.18 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (7.06 mM), Sonication is recommended.
PBS (pH 7.2) : 0.3 mg/mL (1.06 mM), Sonication is recommended.
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| Keywords | NucleosideAntimetabolite | Nucleoside Antimetabolite/Analog | Nucleoside Antimetabolite | Ara-G | AraG | Ara G | Analog |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Adenosine | Floxuridine | 8-Bromoguanosine | Uridine | Capecitabine | 5-BrdU | Vidarabine | Adenosine 5'-monophosphate disodium salt | Cytarabine | 6-Mercaptopurine |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Hematonosis Compound Library | Drug Repurposing Compound Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library | Nucleotide Compound Library |
United States
