| Name | Arecoline |
| Description | Arecoline is a natural alkaloid derived from areca nut in the palm family and is a potent nicotine and partial agonist of muscarinic acetylcholine receptors. Arecoline has anti-anxiety and anti-parasitic activity, can induce oxidative stress and can be used to study Alzheimer's disease and Alzheimer's disease. |
| In vitro | Arecoline induces reactive oxygen species generation and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting p21/Cip1 expression. It also upregulates stress-responsive genes such as hemeoxygenase-1, ferritin light chain, glucose-6-phosphate dehydrogenase, glutamate-cysteine ligase catalytic subunit, and glutathione reductase. At higher concentrations, arecoline causes epithelial cell death due to oxidative trauma without triggering apoptosis[1]. |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (12.89 mM), Sonication is recommended. DMSO : 250 mg/mL (1610.93 mM), Sonication is recommended.
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| Keywords | ReactiveOxygenSpecies | Reactive Oxygen Species | Nicotinic Receptor | AChR |
| Inhibitors Related | Ethoxyquin | Cysteamine hydrochloride | Acetylcysteine | Urethane | L-Ascorbic acid | Dimethyl fumarate | Adenine | L-Cystine | (-)-Epigallocatechin Gallate | L-Ascorbic acid sodium salt | Sodium 2-oxopropanoate | N,N-Dicyclohexylcarbodiimide |
| Related Compound Libraries | Anti-Parasitic Compound Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Antiparasitic Natural Product Library | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |