| Name | Argireline |
| Description | Argireline (Acetyl hexapeptide-3) is a peptide composed of amino acid chains that significantly inhibits Ca2+-dependent neurotransmitter (acetylcholine) release at the neuromuscular junction, exhibiting notable anti-wrinkle and anti-aging activity[1][2][3]. |
| In vitro | The incubation of Argireline solution in varying concentrations with human embryonic kidney HEK-293 (IC50 of 34.862 μM) and neuroblastoma IMR-32 cells (IC50 of 68.458 μM) for 48 hours exhibits a dose-dependent antiproliferative effect. The solution also shows similar effects on HSF cells. Argireline in low concentrations does not affect cell proliferation [2]. |
| In vivo | Argireline was administered topically to elderly mice twice daily for six weeks, resulting in notable histological improvements in skin tissue. Specifically, the quantity of type I collagen fibers increased significantly (P < 0.01), and the amount of type III collagen fibers decreased (P < 0.05). This demonstrates Argireline's capability to enhance the histological architecture of skin tissue and restore aged skin[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 250 mg/mL (281.22 mM)
DMSO : 10 mM, Sonication is recommended.
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| Keywords | skin-permeable | short-chain | peptide | non-toxic | neurotransmitter | Inhibitor | inhibit | BoNTs | Argireline | Antiwrinkle | anti-aging | Acetyl hexapeptide3 | Acetyl hexapeptide 3 |
| Inhibitors Related | Quadrol | Tricaine methanesulfonate | Nisoldipine | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | L-Phenylalanine | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | Calcium Channel Compound Library | Drug Repurposing Compound Library | Peptide Compound Library | NO PAINS Compound Library | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
United States
