| Name | Asperulosidic acid |
| Description | Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways. |
| In vitro | Two novel glycosides, 6-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose and Asperulosidic acid, extracted from the juice of noni fruits, were used to examine their effects on 12-O-tedtradecanoylphorbol-13-acetate (TPA)- and epidermal growth factor (EGF)-induced AP-1 transactivation and cell transformation in mouse epidermal JB6 cells[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.63 mM), Sonication is recommended. DMSO : 65 mg/mL (150.33 mM), Sonication is recommended.
|
| Keywords | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit | Extracellular signal regulated kinases | ERK | EGFR | Asperulosidic acid | AP-1 |
| Inhibitors Related | Urea | Sodium propionate | Gum arabic | Kojic acid | Uridine | Fumaric acid | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | N,N-Dimethylacetamide | Gluconate Calcium | Magnesium sulfate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Pain-Related Compound Library | Rare Natural Product Library | Kinase Inhibitor Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library |