Technical Data Sheet (TDS)
Product Name: Astragaloside IV
Synonyms: Huangqi Triterpene Saponin; Astragaloside A
CAS No.: 84687-43-4
Molecular Formula: C₄₁H₆₈O₁₄
Molecular Weight: 784.97
1. Product Description
Astragaloside IV is a triterpene saponin isolated from the root of Astragalus membranaceus (Huangqi). It is known for its immune-modulating, antioxidant, and cardiovascular protective properties.
It is widely used in nutraceuticals, functional foods, cosmetics, and pharmaceutical intermediates.
2. Specifications
| Name of Index | Specification | Result |
|---|
| Appearance | White to off-white powder | Conforms |
| Odor & Taste | Characteristic | Conforms |
| Identification | Positive (HPLC / TLC) | Positive |
| Assay (HPLC) | ≥ 98% | 98.4% |
| Loss on Drying | ≤ 5% | 2.2% |
| Ash | ≤ 5% | 3.1% |
| Heavy Metals | ≤ 10 ppm | <10 ppm |
| Lead (Pb) | ≤ 3 ppm | <3 ppm |
| Arsenic (As) | ≤ 2 ppm | <2 ppm |
| Cadmium (Cd) | ≤ 1 ppm | <1 ppm |
| Mercury (Hg) | ≤ 0.1 ppm | <0.1 ppm |
| Total Plate Count | ≤ 1,000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤ 100 CFU/g | <10 CFU/g |
| E. coli | Negative | Negative |
| Salmonella | Negative | Negative |
3. Physical & Chemical Properties
| Property | Description |
|---|
| Solubility | Soluble in methanol, ethanol; slightly soluble in water |
| Melting Point | 230–233°C |
| pH (1% solution) | 5.0–7.0 |
| Stability | Stable under normal conditions; sensitive to strong light, heat, and moisture |
| Color Reaction | Yellow in alkaline solution |
4. Applications
Food & Nutraceutical Grade
Functional foods, dietary supplements, herbal beverages, and nutraceutical formulations.
Supports immune system, cardiovascular health, and antioxidant activity.
Typical dosage: 50–200 mg/day depending on formulation.
Industrial & Pharmaceutical Grade
Intermediate for pharmaceutical formulations targeting heart, kidney, and liver protection.
Ingredient in cosmetic formulations for anti-aging and skin protection.
Analytical reference for isolation and quantification of saponins.
5. Safety & Handling
| Aspect | Guideline |
|---|
| Toxicity | Considered safe at recommended dosages. Non-toxic at low concentrations. |
| Handling | Avoid inhalation, skin and eye contact; use protective equipment. |
| Storage | Store in a tightly closed container, in a cool, dry, ventilated place, away from light. |
| Shelf Life | 24 months under proper storage conditions. |
| Packaging | 1 kg aluminum foil bag; 25 kg fiber drum; customized packaging available. |
6. Regulatory Information
Food Grade Compliance: Meets GB 2760 (China), EU Regulation 1333/2008 standards.
Pharmaceutical Reference: Listed in Chinese Pharmacopoeia (ChP).
GMO Status: Non-GMO.
Irradiation: Non-irradiated.
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