| Name | Atipamezole hydrochloride |
| Description | Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride (MPV-1248 hydrochloride) is hydrochloride form of atipamezole. |
| In vitro | The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1]. |
| In vivo | Atipamezole has been found to be well tolerated in rodents and displays only modest cardiovascular effects at dosages ranging from 0.01–1 mg/kg, administered intravenously, in anesthetized, normotensive rats. This compound is frequently utilized by veterinarians to reverse sedation or anesthesia in animals. Additionally, it has been observed to enhance sexual activity in both rats and monkeys. In situations of sustained nociception, atipamezole augments pain-related responses by inhibiting the noradrenergic feedback mechanism that normally suppresses pain. Furthermore, at low doses, atipamezole positively affects several cognitive functions in experimental animals, including alertness, selective attention, planning, learning, and recall, though its impact on short-term working memory remains unclear. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 16.67 mg/mL (67.02 mM), Sonication is recommended.
H2O : 24.9 mg/mL (100.1 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.04 mM), Sonication is recommended.
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| Keywords | α2-adrenoceptor | MPV-1248 Hydrochloride | MPV1248 Hydrochloride | MPV-1248 | MPV1248 | MPV 1248 Hydrochloride | MPV 1248 | Inhibitor | inhibit | Beta Receptor | Atipamezole Hydrochloride | Atipamezole | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Trifluoperazine dihydrochloride | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | D-Mannitol | Mianserin hydrochloride | Trazodone hydrochloride | Atenolol | Doxepin hydrochloride |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Antidepressant Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
United States
